Cancer Weekly
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Acute Myeloid Leukemia
Research conducted at C.C. Hong and co-researchers has updated our knowledge about acute myeloid leukemia
December 16th, 2008
"By using a novel profiling analysis of protein tyrosine kinases differentially expressed in the sensitive and refractory leukemia from the same patients we found that AXL was upregulated in drug-resistant leukemia. Furthermore, AXL could be induced by chemotherapy drugs in the acute myeloid leukemia U937 cells and this induction,vas dependent on the CCWGG methylation status of the AXL promoter," scientists in Taiwan report. "In U937 cells ectopically overexpressing AXL, addition of exogenous Gas6 induced AXL phosphorylation and activation of the Akt and ERK1/2 survival pathways. The Gas6-AXL activation pathway of drug resistance was associated with increased expression...
Source: Cancer Weekly (2008-12-16)
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