Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Apoptosis
Scientists at Chonbuk National University, Medical Department target apoptosis
December 16th, 2008
"Arsenic trioxide (ATO) can regulate many biological functions such as apoptosis and differentiation in various cells. We evaluated the effects of ATO on the viability, cell cycle and apoptosis of human pulmonary adenocarcinoma, Calu-6 and A549 cells," scientists writing in the journal Cancer Letters report. "ATO reduced the viability of Calu-6 cells with an IC50 of approximately 3 or 4 mc M. However, A549 cells were very resistant to ATO. Calu-6 cells treated with 1, 3 or 5 mc M ATO showed a G2 phase arrest of the cell cycle at 72 h. The G2 phase arrest was accompanied with the down-regulation of cdc2 protein. Treatment with ATO-induced apoptosis in Calu-6...
Source: Cancer Weekly (2008-12-16)
|
