Cancer Gene Therapy

Research on cancer gene therapy reported by scientists at National Taiwan University

Published in Cancer Weekly, December 16th, 2008

According to a study from Taipei, Taiwan, "Human hepatocellular carcinoma (HCC) often arises from a background of liver cirrhosis. Therefore, in order to develop therapeutic strategies for HCC, an animal model bearing multifocal liver tumors accompanied by liver cirrhosis is a preferred experimental setting."

"In this study, we developed a rapid and reproducible method for generating such a model in rats by weekly administration of diethylnitrosamine (DEN) at doses based on body weight (BW). By adjusting the duration of administration of DEN, the animals could be induced to develop HCC alone, or HCC and liver cirrhosis simultaneously. The latter model was used for...

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Source: Cancer Weekly (2008-12-16)

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