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Cancer Gene Therapy
Studies from Transgene S.A. in the area of cancer gene therapy published
December 16th, 2008
According to a study from Strasbourg, France, "We have generated a thymidine kinase gene-deleted vaccinia virus (VV) (Copenhagen strain) that expressed the fusion suicide gene FCU1 derived from the yeast cytosine deaminase and uracil phosphoribosyltransferase genes. Intratumoral inoculation of this thymidine kinase gene-deleted VV encoding FCU1 (VV-FCU1) in the presence of systemically administered prodrug 5-fluorocytosine (5-FC) produced statistically significant reductions in the growth of subcutaneous human colon cancer in nude mice compared with thymidine kinase gene-deleted VV treatments or with control 5-fluorouracil alone." "A limitation of prodrug therapies has...
Source: Cancer Weekly (2008-12-16)
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