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Cancer Gene Therapy
Research from Indiana University, Cancer Center provide new insights into cancer gene therapy
December 23rd, 2008
A report, 'c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells,' is newly published data in Biochemical Pharmacology. According to recent research from the United States, "Cellular-FLICE inhibitory protein (c-FLIP) is an inhibitor of apoptosis downstream of the death receptors Fas, DR4, and DR5, and is expressed as long (c-FLIP(L)) and short (c-FLIP(S)) splice forms." "We found that the knockdown of c-FLIP using small interfering RNA (siRNA) triggered ligand-independent caspase-8-and -9-dependent spontaneous apoptosis and decreased the proliferation of MCF-7 breast cancer cells. Further...
Source: Cancer Weekly (2008-12-23)
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