Cancer Weekly
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Cancer Gene Therapy
Researchers from Medical University of South Carolina publish findings in cancer gene therapy
December 23rd, 2008
Data detailed in 'The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription' have been presented. According to recent research published in the American Journal of Physiology - Gastrointestinal and Liver Physiology, "Helicobacter pylori infection of the gastric body induces transient hypochlorhydria and contributes to mucosal progression toward gastric carcinoma. Acid secretion is mediated by parietal cell H,K-ATPase, in which the catalytic alpha-subunit (HKalpha) promoter activity in transfected gastric epithelial [gastric adenocarcinoma (AGS)] cells is repressed by H. pylori through NF-kappaB p50 homodimer binding to the...
Source: Cancer Weekly (2008-12-23)
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