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Gene Therapy
Korea Advanced Institute of Science and Technology publishes research in gene therapy
December 23rd, 2008
Investigators publish new data in the report 'Amine-functionalized gold nanoparticles as non-cytotoxic and efficient intracellular siRNA delivery carriers.' According to recent research from South Korea, "Gold nanoparticles chemically modified with primary amine groups were developed as intracellular delivery vehicles for therapeutic small interfering RNA (siRNA). The positively charged gold nanoparticles could form stable polyelectrolyte complexes through electrostatic interactions with negatively charged siRNA-polyethylene glycol (PEG) conjugates having a cleavable di-sulfide linkage under reductive cytosol condition." "The resultant core/shell type polyelectrolyte...
Source: Cancer Weekly (2008-12-23)
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