Cancer Weekly
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Apoptosis
Study data from Karolinska University update understanding of apoptosis
December 23rd, 2008
"p53 mutations occur frequently in human tumors. The low-molecular-weight compound PRIMA-1(MET) reactivates mutant p53, induces apoptosis in human tumor cells and inhibits tumor xenograft growth in vivo," investigators in Stockholm, Sweden report. "Here, we show that PRIMA-1(MET) induces mutant p53-dependent mito-chondria-mediated apoptosis through activation of caspase-2 with subsequent cytochrome c release and further activation of downstream caspase-9 and caspase-3. Inhibition of caspase-2 by a selective inhibitor and/or siRNA prevents cytochrome c release on PRIMA-1(MET) treatment and causes a significant reduction in PRIMA-1(MET)-induced cell death. Our findings...
Source: Cancer Weekly (2008-12-23)
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