Cancer Weekly
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Cancer Gene Therapy
Data on cancer gene therapy detailed by researchers at University of Ghent
December 23rd, 2008
According to recent research published in the journal Oncogene, "The epidermal growth factor receptor (EGFR) is frequently overexpressed in various tumours of epidermal origin and is held responsible for tumourigenicity and tumour persistence. Increased nuclear factor (NF)-kappa B activity has been suggested to be involved in the malignant behaviour of EGFR-overexpressing cells." "However, the mechanisms that regulate EGF-induced NF-kappa B activation are still largely unknown. Here we show that EGF can induce NF-kappa B-dependent gene expression independently from I kappa B alpha degradation or p100 processing in EGFR-overexpressing HEK293T cells. Moreover,...
Source: Cancer Weekly (2008-12-23)
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