Cancer Weekly
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Breast Cancer
Research on breast cancer reported by scientists at University of Michigan
December 23rd, 2008
According to recent research published in the journal Oncogene, "The cancer stem cell hypothesis proposes that cancers arise in stem/progenitor cells through disregulation of self-renewal pathways generating tumors, which are driven by a component of 'tumor-initiating cells' retaining stem cell properties. The HER2 gene is amplified in 20-30% of human breast cancers and has been implicated in mammary tumorigenesis as well as in mediating aggressive tumor growth and metastasis." "We demonstrate that HER2 overexpression drives mammary carcinogenesis, tumor growth and invasion through its effects on normal and malignant mammary stem cells. HER2 overexpression in...
Source: Cancer Weekly (2008-12-23)
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