Cancer Weekly
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Cancer
Findings in cancer reported from Christian Medical College, Medical College
December 23rd, 2008
"Methotrexate (MTX), a structural analogue of folic acid, is widely used as a chemotherapeutic agent for leukemia and other malignancies. One of the major toxic effects of MTX is intestinal injury and enterocolitis The mechanism of gastrointestinal toxicity of methotrexate has not been investigated completely," investigators in Vellore, India report. "Therefore cancer chemotherapy has to be accompanied by symptomatic therapy such as antibiotics and anti-diarrheal drugs. It is important to investigate the mechanism by which methotrexate induces intestinal damage in order to perform cancer chemotherapy effectively by preventing the side effects. This study aimed at...
Source: Cancer Weekly (2008-12-23)
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