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Cancer Gene Therapy
Research from Shandong University in cancer gene therapy provides new insights
December 30th, 2008
According to a study from Jinan, People's Republic of China, "Hepatocellular carcinoma (HCC), one of the most common cancers worldwide, is resistant to anticancer drugs. Hypoxia is a major cause of tumor resistance to chemotherapy, and hypoxia-inducible factor (HIF)-1 is a key transcription factor in hypoxic responses." "We have previously demonstrated that gene transfer of an antisense HIF-1 alpha expression vector downregulates expression of HIF-1 alpha and vascular endothelial growth factor (VEGF), and synergizes with immunotherapy to eradicate lymphomas. The aim of the present study was to determine whether gene transfer of antisense HIF-1 alpha could enhance the...
Source: Cancer Weekly (2008-12-30)
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