Cancer

Researchers' work from University of Pittsburgh focuses on cancer

Published in Cancer Weekly, December 30th, 2008

According to recent research from the United States, "Increased expression of PSMA, a differentiation antigen with folate hydrolase activity is an independent marker of prostate cancer progression. Mice expressing moderate levels of human PSMA in their prostate develop PIN-like lesions by 9 months."

"The aim of this study was to determine whether PSMA is involved in prostate carcinogenesis and progression and, if so, the possible mechanism by which PSMA may exert its effects. Using prostates from PSMA-transgenic mice, we developed a tissue recombinant model that exhibits small atypical glands with features of adenocarcinoma. This was not observed in tissue recombinants...

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Source: Cancer Weekly (2008-12-30)

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