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Apoptosis Gene Therapy
New apoptosis gene therapy data have been reported by I. Carmona-Cuenca and co-authors
December 30th, 2008
A report, 'Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity,' is newly published data in Journal of Hepatology. "The transforming growth factor-beta (TGF-beta) induces apoptosis in hepatocytes through an oxidative stress process. Here, we have analyzed the role of different NADPH oxidase isoforms in the intracellular signalling induced by TGF-beta in hepatocytes, to later explore whether this mechanism is altered in liver tumor cells," scientists in Madrid, Spain report. "Primary cultures of rat and human hepatocytes, HepG2 and Hep3B cells were used in in vitro studies to analyze the TGF-beta response....
Source: Cancer Weekly (2008-12-30)
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