Cancer Weekly
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Cancer Gene Therapy
Reports from University of Texas, M.D. Anderson Cancer Center describe recent advances in cancer gene therapy
December 30th, 2008
New investigation results, 'The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells,' are detailed in a study published in The Journal of Clinical Investigation. "The role of autophagy in oncogenesis remains ambiguous, and mechanisms that induce autophagy and regulate its outcome in human cancers are poorly understood. The maternally imprinted Ras-related tumor suppressor gene aplasia Ras homolog member I (ARHI; also known as DIRAS3) is downregulated in more than 60% of ovarian cancers, and here we show that re-expression of ARHI in multiple human ovarian cancer cell lines induces autophagy by blocking PI3K signaling and inhibiting...
Source: Cancer Weekly (2008-12-30)
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