Life Sciences

New findings from M.J. Bueno and co-authors in the area of life sciences published

Published in Cancer Weekly, December 30th, 2008

According to recent research published in the journal Cell Cycle, "MicroRNAs (miRNAs) are small non-coding RNAs that regulate a large variety of cellular processes including differentiation, apoptosis and proliferation. Several miRNAs display defective expression patterns in human tumors with the consequent alteration of target oncogene or tumor suppressor genes."

"Many of these miRNAs modulate the major proliferation pathways through direct interaction with critical regulators such as RAS, PI3K/PTEN or ABL, as well as members of the retinoblastoma pathway, Cyclin-CDK complexes or cell cycle inhibitors of the INK4 or Cip/Kip families. A complex interplay between...

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Source: Cancer Weekly (2008-12-30)

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