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Gene Therapy
Researchers from St. Vincent's Hospital, Department of Orthopaedics discuss findings in gene therapy
December 30th, 2008
New investigation results, 'Biocompatible chitosan-dnazyme nanoparticle exhibits enhanced biological activity,' are detailed in a study published in Journal of Microencapsulation. "DNAzymes are oligonucleotides capable of specific catalysis of target mRNA. To date, a delivery vehicle for DNAzymes has not been developed," investigators in Australia report. "Chitosan is a biomaterial obtained abundantly in nature. A biocompatible c-jun (an oncogene) DNAzyme nanoparticle formulated from chitosan was found to be more active against osteosarcoma (bone cancer) cells, inducing apoptotic cell death in these cells. The formulation was stable in serum for a week and at...
Source: Cancer Weekly (2008-12-30)
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