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Life Sciences
Investigators at University of Bonn, Department of Internal Medicine I release new data on life sciences
December 30th, 2008
Data detailed in 'siRNA targeting VEGF inhibits hepatocellular carcinoma growth and tumor angiogenesis in vivo' have been presented. According to a study from Bonn, Germany, "We have investigated whether siRNA targeted against VEGF inhibits functional properties of endothelial cells in vitro and HCC tumor growth and blood vessel formation in vivo. The influence of siRNA-VEGF on endothelial cell proliferation, apoptosis and tube formation were analyzed in vitro." "Antitumoral effects were examined in an orthotopic tumor model after ex vivo transfer or intraperitoneal treatment of siRNA, respectively. Intratumoral microvessel density was assessed by CD31 staining. VEGF...
Source: Cancer Weekly (2008-12-30)
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