Cancer Weekly
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Adenocarcinoma
Reports from J.S. Delgado et al highlight recent research in adenocarcinoma
December 30th, 2008
According to recent research published in the journal Digestive Diseases and Sciences, "Background and purpose Current therapies offer scant benefit to patients with advanced esophageal adenocarcinoma. We investigated the effects of Sorafenib, a multifunctional kinase inhibitor, on several growth regulatory pathways that control cell growth and survival in SEG-1 cells derived from Barrett's adenocarcinoma." " SEG-1 cells were exposed to acidified medium or taurocholic acid, with and without pre-incubation with Sorafenib. Cyclin D1 and E, c-Myc, and Bcl-2 expression levels as well as STAT3 activations were determined by Western blotting. Cyclin D1 mRNA was...
Source: Cancer Weekly (2008-12-30)
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