Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy research from University of Pittsburgh outlined
December 30th, 2008
"Recombinant adenoviral vectors (AdV) are potent vehicles for antigen engineering of dendritic cells (DC). DC engineered with AdV to express full length tumor antigens are capable stimulators of antigen-specific polyclonal CD8+ and CD4+ T cells," scientists writing in the journal Cancer Immunology Immunotherapy report. "To determine the impact of AdV on the HLA class I antigen presentation pathway, we investigated the effects of AdV transduction on antigen processing machinery (APM) components in human DC. Interactions among AdV transduction, maturation, APM regulation and T cell activation were investigated. The phenotype and cytokine profile of DC transduced...
Source: Cancer Weekly (2008-12-30)
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