Cancer Weekly
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Angiogenesis
Research reports on angiogenesis from C.F.J.M. Peeters and colleagues provide new insights
December 30th, 2008
"In cancer patients, occult micrometastases may become apparent shortly after removal of the primary tumor. Animal experiments have shown that metastatic dormancy is maintained by apoptosis, and that primary tumor removal induces a flare-up of angiogenesis, leading to metastatic outgrowth," scientists in Nijmegen, Netherlands report. "This phenomenon has led to the hypothesis that the primary tumor generates certain factors that inhibit angiogenesis at distant sites. It is still unknown whether such a phenomenon is operative in human cancer as well. Should it occur, it might have important therapeutic consequences. Evidence for such a mechanism may be obtained from...
Source: Cancer Weekly (2008-12-30)
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