Cancer Weekly
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Angiogenesis
Studies from Ehime University, Medical Department add new findings in the area of angiogenesis
December 30th, 2008
According to recent research from Japan, "We reported that the antitumor and antimetastatic actions of resveratrol might be due to the inhibition of tumor-induced angiogenesis. To search for anticancer agents with stronger activity than resveratrol, we examined the antiangiogenic effects of 21 synthetic and/or natural stilbenes." "Among these 21 stilbenes, 2,3-, 3,4-, and 4,4'-dihydroxystilbene inhibited the pro-matrix metalloproteinase (pro-MMP)-9 production in colon 26 cells at 5-25 mc M, vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cell (HUVEC) migration at 10 and 25 mc M, and VEGF-induced angiogenesis at 5-50 mc M. Resvertarol...
Source: Cancer Weekly (2008-12-30)
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