Cancer Weekly
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Astrocytoma
Recent findings in astrocytoma described by researchers from Addenbrooke's Hospital
December 30th, 2008
According to recent research from Box, the United Kingdom, "Brain tumors are the most common solid tumors of childhood, and pilocytic astrocytomas (PA) are the most common central nervous system tumor in 5 to 19 year olds. Little is known about the genetic alterations underlying their development." "Here, we describe a tandem duplication of similar to 2 Mb at 7q34 occurring in 66% of As. This rearrangement, which was not observed in a series of 244 higher-grade astrocytomas, results in an in-frame fusion gene incorporating the kinase domain of the BRAF oncogene. We further show that the resulting fusion protein has constitutive BRAF kinase activity and is able to...
Source: Cancer Weekly (2008-12-30)
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