Cancer Weekly
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Gene Therapy
Research findings from L.J. Duerner et al update understanding of gene therapy
January 6th, 2009
"Virotherapy is currently being developed for many different types of viruses including replication-competent murine leukaemia virus (MLV) as a novel tool in cancer therapy. However, there is the risk of insertional mutagenesis associated with this virus, making careful preclinical studies necessary before its first application in man," scientists writing in the journal Gene Therapy report. "We have previously generated conditionally replication-competent MLV variants that require activation by tumour-associated proteases to become infectious. Here we analysed in a comparative study the spreading of non-targeted and of such tumour-targeted MLV variants to tumour...
Source: Cancer Weekly (2009-01-06)
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