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Cancer Gene Therapy
Scientists at University of Texas, M. D. Anderson Cancer Center publish research in cancer gene therapy
January 6th, 2009
Scientists discuss in '1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth' new findings in cancer gene therapy. "Nurr1 is an orphan nuclear receptor and a member of the nerve growth factor I-B subfamily of transcription factors with no known endogenous ligand or stimulator. We show, for the first time, evidence that Nurr1 is expressed in a panel of 11 human bladder cancer cell lines," scientists writing in the journal Molecular Cancer Therapeutics report. "A new class of methylene-substituted diindolylmethanes (C-DIM) were screened and 1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methane...
Source: Cancer Weekly (2009-01-06)
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