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Melanoma Gene Therapy
Data on melanoma gene therapy published by M. Zheng and colleagues
January 6th, 2009
Fresh data on melanoma are presented in the report 'Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.' According to recent research published in the journal Molecular Cancer Therapeutics, "Melanoma is the most malignant of skin cancers, highly resistant to chemotherapy and radiotherapy. Temozolomide, a promising new derivative of dacarbazine, is currently being tested for treatment of metastatic melanoma." "Resistance to alkylating agents such as temozolomide correlates with increased expression of DNA repair protein O6-methylguanine-DNA methyltransferase...
Source: Cancer Weekly (2009-01-06)
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