Enzyme Research

Researchers from University of East Anglia publish findings in enzyme research

Published in Cancer Weekly, January 6th, 2009

"Increasing evidence places the epithelial cell at the centre of inflammatory processes in human airways. Crucial to this function and the maintenance of inflammatory homoeostasis is a balanced oxidant-antioxidant status in the airway, in part controlled by thioredoxin and thioredoxin reductase, which together can alter the NF-kappa B pathway," scientists in Norwich, the United Kingdom report.

"PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, has been investigated in endothelial cells, fibroblasts and colorectal cancer cell lines but in the present issue of the BJP, these investigations were extended to A549 airway epithelial cells. Thioredoxin...

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Source: Cancer Weekly (2009-01-06)

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