Helicobacter pylori
Researchers from Vanderbilt University report details of new studies and findings in the area of helicobacter pylori
Published in Cancer Weekly, January 6th, 2009
"Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, yet only a fraction of infected persons develop cancer. One H. pylori constituent that augments disease risk is the cytotoxin-associated gene (cag) pathogenicity island, which encodes a secretion system that translocates bacterial effector molecules into host cells. Matrix metalloproteinase (MMP)-7, a member of a family of enzymes with tumor-initiating properties, is overexpressed in premalignant and malignant gastric lesions, and H. pylori cag(+) strains selectively increase MMP-7 protein levels in gastric epithelial cells in vitro and in vivo," scientists writing in the journal Molecular Biology of the...
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Source: Cancer Weekly (2009-01-06)
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