Cancer Weekly
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Adenomatous Polyposis Coli
Researchers at University of Kansas target adenomatous polyposis coli
January 6th, 2009
According to recent research from the United States, "The tumor suppressor adenomatous polyposis coli (APC) is implicated in regulating multiple stages of the cell cycle. APC participation in G1/S is attributed to its recognized role in Wnt signaling." "APC function in the G2/M transition is less well established. To identify novel protein partners of APC that regulate the G2/M transition, APC was immunoprecipitated from colon cell lysates and associated proteins were analyzed by matrix-assisted laser desorption ionization/time of flight (MALDI-TOF). Topoisomerase II alpha (topo II alpha) was identified as a potential binding partner of APC. Topo II alpha is a critical...
Source: Cancer Weekly (2009-01-06)
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