Medulloblastoma

Studies from P. Fiorilli and colleagues reveal new findings on medulloblastoma

Published in Cancer Weekly, January 6th, 2009

"Medulloblastoma spreads by leptomeningeal dissemination rather than by infiltration that characterizes other CNS tumors, eg, gliomas. This study represents an initial attempt to identify both the molecules that mediate medulloblastoma adhesion to leptomeninges and the pathways that are key to survival and proliferation of tumor following adhesion," investigators in Toronto, Canada report.

"As a first step in molecule identification, we produced adhesion of D283 medulloblastoma cells to the extracellular matrix (ECM) of H4 glioma cells in vitro. Within this context, D283 cells preferentially expressed the alpha 9 and beta 1 integrin subunits; antibody and disintegrin...

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Source: Cancer Weekly (2009-01-06)

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