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Apoptosis
Study findings from Nanjing University provide new insights into apoptosis
January 6th, 2009
According to recent research published in the journal Methods and Findings in Experimental and Clinical Pharmacology, "Arsenic trioxide (ATO) is known to have concentration-dependent dual effects on acute promyelocytic leukemia (APL) cells, preferentially inducing apoptosis at relatively high concentrations and promoting partial differentiation at low concentrations. Protein phosphatase 2A (PP2A) has been demonstrated to take part in the differentiation and apoptosis of malignant hematological cells induced by commonly used medicines, such as all-trans-retinoic acid (ATRA), interferon, arsenic sulfide, etc." "However, there are almost no data on the role PP2A...
Source: Cancer Weekly (2009-01-06)
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