Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy findings from Jikei University, Medical Department described
January 6th, 2009
According to recent research published in the journal Anticancer Research, "We have explored a gene-therapeutic approach to stimulate antitumor immunity by adenoviral-mediated transfer of CD40 ligand (CD40L) to treat metastatic liver cancer in a rat model. Rat metastatic liver cancer cells were implanted into the back of rats bilaterally." "When the larger tumor reached 8.0 mm in diameter, adenovirus vector-expressing mouse CD40L was injected intratumorally as treatment group (n=5), while LacZ was injected in the control group (n=5). In the control group, the tumor gradually grew to be 20.7 +/- 1.6 (mean +/- SD) mm in intratumorally injected tumors and 21.8 +/-...
Source: Cancer Weekly (2009-01-06)
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