Cancer Weekly
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Apoptosis
Study results from University of Calgary, Medical Department provide new insights into apoptosis
January 6th, 2009
According to a study from Calgary, Canada, "ING proteins interact with core histones through their plant homeodomains (PHDs)(1-4) and with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes to alter chromatin structure(5-7). Here we identify a lamin interaction domain (LID) found only in ING proteins, through which they bind to and colocalize with lamin A. Lamin knockout (LMNA(-/-)) cells show reduced levels of ING1 that mislocalize." "Ectopic lamin A expression increases ING1 levels and re-targets it to the nucleus to act as an epigenetic regulator(6,8). ING1 lacking the LID does not interact with lamin A or affect apoptosis. In LMNA-/- cells,...
Source: Cancer Weekly (2009-01-06)
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