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Apoptosis Cell Biology

New findings from University of Lleida in the area of apoptosis cell biology published

Published in Cancer Weekly, January 6th, 2009

A report, 'BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis,' is newly published data in Molecular Cancer Therapeutics. "In previous reports, we have shown in SH-SY5 cells that olomoucine and roscovitine, two inhibitory drugs of cyclin-dependent kinases, caused apoptosis independent of the extrinsic pathway. In this experimental paradigm, apoptosis was refractory to the protective effects of either Bcl-2 or Bcl-XL overexpression," scientists in Spain report.

"We are now reporting that the failure of Bcl-XL to prevent dell death was consistent with no effect on the kinetics of caspase activation and cytochrome c...

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