Cancer Weekly
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Breast Cancer
Findings from J. Stagg et al in breast cancer reported
January 6th, 2009
"Despite the development of human epidermal growth factor receptor-2 (ErbB-2/HER2)-targeted therapies, there remains an unmet medical need for breast cancer patients with ErbB-2 overexpression. We investigated the therapeutic activity of an agonist mAb to mouse tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 (DR5) against ErbB2-driven breast cancer," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report. "Established tumors in BALB/c transgenic mice expressing a constitutively active ErbB-2/neuT were treated with anti-DR5 mAb and/or anti-ErbB-2 mAb and monitored for...
Source: Cancer Weekly (2009-01-06)
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