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Cancer Weekly

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Cancer Gene Therapy



Studies from University of Heidelberg, Department of Urology in the area of cancer gene therapy published



January 13th, 2009

Current study results from the report, 'Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma,' have been published. "We report on cytotoxic effects of bcl-2 and bcl-xL antisense-oligodeoxynucleotides (AS-ODNs) in benign urothelial and transitional cell carcinoma (TCC) cell lines. The benign urothelial cell line (UROtsa) and four TCC cell lines (UM-UC-3, RT 112 , HT 1197 and T 24/83) were incubated with bcl-2 and bcl-xL AS-ODNs and cell mortality rates were assessed," investigators in Mannheim, Germany report.

"Bcl-2 and bcl-xL AS-ODN treatment resulted in low toxicity in UROtsa...


Source: Cancer Weekly (2009-01-13)

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