Cancer Weekly
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Acute Leukaemia
New acute leukaemia findings from M. Mosor and co-authors described
January 13th, 2009
"DNA repair gene polymorphisms and mutations may influence cancer risk. The product of the NBS1 gene, nibrin, is functionally involved in the double-strand DNA break repair system," researchers in Poznan, Poland report. "Heterozygous, germline mutations of the NBS1 gene are associated with an increased risk of tumours. Thus, common polymorphism and haplotypes of NBS1 may contribute to the risk of cancer. This study verified whether polymorphisms of the NBS1 gene may influence susceptibility to the development of childhood acute leukaemia. We genotyped six polymorphisms of the NBS1 gene in 157 children with acute leukaemia and 275 controls. The TT genotype of c.2071-30A...
Source: Cancer Weekly (2009-01-13)
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