Cancer Weekly
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Angiogenesis
New findings from University of Oulu describe advances in angiogenesis
January 13th, 2009
According to recent research published in the journal Experimental Cell Research, "Physiological and pathological turnover of basement membranes liberates biologically active cryptic molecules. Several collagen-derived fragments possess anti-angiogenic activity." "Arresten is the 26-kDa non-collagenous domain of type IV collagen alpha 1 chain. It functions as an efficient inhibitor of angiogenesis and tumor growth in mouse models, but its anti-angiogenic mechanism is not completely known. Here we show that arresten significantly increases apoptosis of endothelial cells in vitro by decreasing the amount of anti-apoptotic molecules of the Bcl-family: Bcl-2 and...
Source: Cancer Weekly (2009-01-13)
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