Cancer Weekly
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Angiogenesis
Researchers from University of California discuss findings in angiogenesis
January 13th, 2009
"Angiogenesis and the development of a vascular network are required for tumour progression, and they involve the release of angiogenic factors, including vascular endothelial growth factor ( VEGF-A), from both malignant and stromal cell types(1). Infiltration by cells of the myeloid lineage is a hallmark of many tumours, and in many cases the macrophages in these infiltrates express VEGF-A(2)," scientists writing in the journal Nature report. "Here we show that the deletion of inflammatory-cell-derived VEGF- A attenuates the formation of a typical high-density vessel network, thus blocking the angiogenic switch in solid tumours in mice. Vasculature in tumours...
Source: Cancer Weekly (2009-01-13)
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