Cancer Weekly
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Apoptosis
Reports from Y. Sasaki et al highlight recent research in apoptosis
January 13th, 2009
"X-Linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis protein family that is overexpressed in human cancers. There is great interest in the development of XIAP inhibitors, which are predicted to promote apoptosis in cancer cells and thus have therapeutic potential," researchers in Sendai, Japan report. "A cyclic hexapeptide (CH), CPFKQC, which is one of the consensus motifs that can bind to the baculovirus IAP repeat 2 domain of XIAP, has been identified using phage-displayed combinatorial chemistry techniques [Tamm I, Trepel M, Cardo-Vila M, Sun Y, Welsh K, Cabezas E, Swatterthwait A, Arap W, Reed JC & Pasqualini R (2003) Peptides...
Source: Cancer Weekly (2009-01-13)
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