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Cancer Weekly

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Apoptosis



Study findings from M. Kobori et al provide new insights into apoptosis



January 13th, 2009

"Bitter gourd (Momordica charantia L.) pericarp, placenta, and seed extracts were previously shown to induce apoptosis in HL60 human leukemia cells. To determine the active component that induces apoptosis in cancer cells, bitter gourd ethanol extract was fractionated by liquid-liquid partition and silica gel column chromatography," researchers in Tsukuba, Japan report.

"Several fractions obtained by silica gel column chromatography inhibited growth and induced apoptosis in HL60 cells. Among them, fraction 7 had the strongest activity in inhibiting growth and inducing apoptosis in HL60 cells. A component that induced apoptosis in HL60 cells was then isolated from...


Source: Cancer Weekly (2009-01-13)

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