Cancer Weekly
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Bladder Cancer
Research from C.L. Chen and co-authors in the area of bladder cancer published
January 13th, 2009
"Constitutive activation of signal transducer and activator of transcription 3 (Stat3) signaling pathway plays an important role in several human cancers. Activation of Stat3 is dependent on the phosphorylation at the tyrosine residue 705 by upstream kinases and subsequent nuclear translocation after dimerization," researchers in the United States report. "It remains unclear whether oncogenic Stat3 signaling pathway is involved in the oncogenesis of bladder cancer. We found that elevated Stat3 phosphorylation in 19 of 100 (19%) bladder cancer tissues as well as bladder cancer cell lines, WH, UMUC-3 and 253J. To explore whether Stat3 activation is associated with cell...
Source: Cancer Weekly (2009-01-13)
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