Breast Cancer
Research from S. Rottenberg and co-authors yields new data on breast cancer
Published in Cancer Weekly, January 20th, 2009
"Whereas target-specific drugs are available for treating ERBB2-overexpressing and hormone receptor-positive breast cancers, no tailored therapy exists for hormone receptor- and ERBB2-negative (''triple-negative'') mammary carcinomas. Triple-negative tumors account for 15% of all breast cancers and frequently harbor defects in DNA double-strand break repair through homologous recombination (HR), such as BRCA1 dysfunction," scientists in Netherlands report.
"The DNA-repair defects characteristic of BRCA1-cleficient cells confer sensitivity to poly(ADP-ribose) polymerase 1 (PARP1) inhibition, which could be relevant to treatment of triple-negative tumors. To evaluate...
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Source: Cancer Weekly (2009-01-20)
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