Cancer Gene Therapy
Emory University, Division of Digestive Diseases publishes research in cancer gene therapy
Published in Cancer Weekly, January 20th, 2009
New investigation results, 'Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium,' are detailed in a study published in Molecular Cancer Research. According to recent research published in the journal Molecular Cancer Research, "The zinc finger-containing transcription factor, Krüppel-like factor 4 (KLF4), inhibits cell proliferation. An in vivo tumor-suppressive role for KLF4 is shown by the recent finding that Klf4 haploinsufficiency in Apc(Min/+) mice promotes intestinal tumorigenesis."
"Studies also show that KLF4 is required for the terminal differentiation of goblet cells in the mouse intestine. The...
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Source: Cancer Weekly (2009-01-20)
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