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Cancer Gene Therapy
Emory University, Division of Digestive Diseases publishes research in cancer gene therapy
January 20th, 2009
New investigation results, 'Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium,' are detailed in a study published in Molecular Cancer Research. According to recent research published in the journal Molecular Cancer Research, "The zinc finger-containing transcription factor, Krüppel-like factor 4 (KLF4), inhibits cell proliferation. An in vivo tumor-suppressive role for KLF4 is shown by the recent finding that Klf4 haploinsufficiency in Apc(Min/+) mice promotes intestinal tumorigenesis." "Studies also show that KLF4 is required for the terminal differentiation of goblet cells in the mouse intestine. The...
Source: Cancer Weekly (2009-01-20)
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