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Gene Therapy
University of California details research in gene therapy
January 20th, 2009
Research findings, 'Menin promotes the Wnt signaling pathway in pancreatic endocrine cells,' are discussed in a new report. "Menin is a tumor suppressor protein mutated in patients with multiple endocrine neoplasia type 1. We show that menin is essential for canonical Wnt/beta-catenin signaling in cultured rodent islet tumor cells," scientists writing in the journal Molecular Cancer Research report. "In these cells, overexpression of menin significantly enhances TCF gene assay reporter activity in response to beta-catenin activation. Contrastingly, inhibition of menin expression with Men1 siRNA decreases TCF reporter gene activity. Likewise, multiple endocrine...
Source: Cancer Weekly (2009-01-20)
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