Cancer Weekly
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African Trypanosomiasis
New findings reported from University of California describe advances in african trypanosomiasis
January 20th, 2009
According to a study from the United States, "Trypanosomatid RNA editing is a unique process and essential for these organisms. It therefore represents a drug target for a group of protozoa that includes the causative agents for African sleeping sickness and other devastating tropical and subtropical diseases." "Here, we present drug-like inhibitors of a key enzyme in the editing machinery, RNA-editing ligase 1 (REL 1). These inhibitors were identified through a strategy employing molecular dynamics to account for protein flexibility. A virtual screen of the REL 1 crystal structure against the National Cancer Institute Diversity Set was performed by using AutoDock4. The...
Source: Cancer Weekly (2009-01-20)
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