Cancer Weekly
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Apoptosis
Studies from University of Munich yield new information about apoptosis
January 20th, 2009
"Cephalostatin 1 is a natural compound isolated from a marine worm that induces apoptosis in tumor cells via an apoptosome-independent but caspase-9-dependent pathway and through an endoplasmic reticulum stress response that is accompanied by caspase-4 activation. Here, we show that cephalostatin evokes mitochondrial Smac (second mitochondria-derived activator of caspases) but not cytochrome c release in various carcinoma cell lines," scientists writing in the journal Cell Death and Differentiation report. "We also show that Smac is critically involved in caspase-9 activation as evidenced by gene silencing experiments. Remarkably, caspase-2 appears to be a major...
Source: Cancer Weekly (2009-01-20)
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