Cancer

Research results from Hebrew University, Medical Department update knowledge of cancer

Published in Cancer Weekly, January 27th, 2009

"The p53 tumor suppressor protein is a transcription factor that plays a key role in the cellular response to stress and cancer prevention. Upon activation, p53 regulates a large variety of genes causing cell cycle arrest, apoptosis, or senescence," investigators in Jerusalem, Israel report.

"We have developed a p53-focused array, which allows us to investigate, simultaneously, p53 interactions with most of its known target sequences using the chromatin immunoprecipitation (ChIP)-on-chip methodology. Applying this technique to multiple cell types under various growth conditions revealed a profound difference in p53 activity between primary cells and established cell...

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Source: Cancer Weekly (2009-01-27)

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