Cedars-Sinai Medical Center

Gene therapy eliminates brain tumors through selective recruitment of immune cells

Published in Cancer Weekly, January 27th, 2009

Scientists seeking to harness the power of the immune system to eradicate brain tumors face two major hurdles: recruiting key immune cells called dendritic cells into areas of the brain where they are not naturally found and helping them recognize tumor cells as targets for attack.

Researchers at Cedars-Sinai Medical Center, however, have identified a sequence of molecular events that accomplish both objectives. Their findings, based on laboratory and animal studies, appear in the Jan. 13 issue of PLoS Medicine, an open-access online journal of the Public Library of Science.

The Cedars-Sinai team discovered that a protein – HMGB1 – released from...

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Source: Cancer Weekly (2009-01-27)

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