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Cancer Gene Therapy
Researchers from National Institutes of Health report on findings in cancer gene therapy
January 27th, 2009
Researchers detail in 'Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells,' new data in cancer gene therapy. "Carcinoembryonic antigen (CEA) is a tumor-associated protein expressed on a variety of adenocarcinomas. To develop an immunotherapy for patients with cancers that overexpress CEA, we isolated and genetically modified a T-cell receptors (TCRs) that specifically bound a CEA peptide on human cancer cells," scientists in the United States report. "HLA-A2.1 transgenic mice were immunized with CEA:691-699. A CEA-reactive TCR was isolated from splenocytes of these...
Source: Cancer Weekly (2009-01-27)
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